LIFE OF SLBP, A MAJOR PLAYER IN HISTONE BIOSYNTHESIS

Djakbarova, U. (2016) LIFE OF SLBP, A MAJOR PLAYER IN HISTONE BIOSYNTHESIS. Scientific-Practical Journal of Medicine, "Vestnik KazNMU" (4). ISSN 2524 - 0692

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Abstract

Cells need to achieve very delicate balance between DNA synthesis and histone levels and ensure the synthesis of histone proteins just during the S phase where the DNA is being replicated. Restriction of histone biosynthesis to S phase is critical for maintenance of genomic stability and proper gene regulation. Many transcriptional and posttranscriptional factors contribute coordinately to regulate expression of histone proteins, including transcription of histone genes, efficiency of pre-mRNA processing (the percentage of mature mRNA that reach to cytoplasm), change in mRNA half- life and degradation of excess histone proteins. Stem-Loop Binding Protein (SLBP), which binds to 3’ ends of histone mRNAs, is a key factor in histone biosynthesis. SLBP expression is cell cycle regulated without significant change in its mRNA level and this regulation is responsible for occurrence of bulk histone production during S phase. SLBP level is high during S phase and low in M and G1 phase until next S phase. It has been found that SLBP is degraded at the end of S phase due on double phosphorylation triggered by CyclinA/CDK2 and similarly in G1, the SLBP stability seems to be low. SLBP protein, which is not degraded at the end of S phase was found to be toxic for cells and effects the rate of DNA replication. These findings show that S phase limited expression of SLBP is very critical for histone mRNA biosynthesis.

Item Type:	Article
Uncontrolled Keywords:	Stem Loop Binding Protein (SLBP), histone mRNA, cell cycle, protein degradation, histone mRNA processing.
Subjects:	Материалы семинаров и конференций > Материалы семинаров и конференций КазНМУ
Divisions:	Научно-практический журнал "Вестник КазНМУ" > Выпуск №4 2016 год
Depositing User:	Mr Askhat Zhakaev
Date Deposited:	06 Jun 2018 11:10
Last Modified:	06 Jun 2018 11:10
URI:	http://repository.kaznmu.kz/id/eprint/15130

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