ASSESSMENT OF EXECUTIVE FUNCTIONS IN THE FRONTAL LOBE OF THE BRAIN AND THE PRESENCE OF DEMENTIA PATIENTS WITH TYPE 2 DIABETES MELLITUS ON A CONTINUOUS SUBCUTANEOUS INSULIN INFUSION

Seidinova, А.Sh. (2019) ASSESSMENT OF EXECUTIVE FUNCTIONS IN THE FRONTAL LOBE OF THE BRAIN AND THE PRESENCE OF DEMENTIA PATIENTS WITH TYPE 2 DIABETES MELLITUS ON A CONTINUOUS SUBCUTANEOUS INSULIN INFUSION. Scientific-Practical Journal of Medicine, "Vestnik KazNMU" (1). ISSN 2524 - 0692

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Abstract

Background: Cognitive impairment becomes a problem in the 21st century, due to increasing background diseases leading to this problem. It should be noted that the average age of mankind increases, respectively, the executive functions of the brain among the population of the Earth is also getting older. Dementia and cognitive functions of the brain are undoubtedly relevant topics today. Diabetes mellitus is a background factor that leads to dementia and memory impairment [1]. Aim: to study the presence of impaired executive function of the frontal lobes of the brain and dementia among patients with type 2 diabetes mellitus on a continuous subcutaneous insulin infusion and multiple daily insulin injection therapy from 45 to 65 years, according to the experi-ence of diabetes from 5 years and above. Materials and methods: 210 patients with type 2 diabetes were studied. The main group consisted of patients with type 2 diabetes using the method of treatment as a permanent subcutaneous insulin infusion (n = 105), in the control group there were patients with type 2 diabetes on multiple insulin injection therapy (n = 105). Patients were selected from two study groups according to age: from 45 to 65 years, according to the experience of diabetes were selected from 5 years and above. The presence of impaired executive functions of the frontal lobes of the brain and presence of dementia were determined using the clock drawing test. Results: In our research work, the cognitive functions (executive work) of the frontal lobe of the brain and the presence of dementia in patients with type 2 diabetes (n = 210) were studied for two methods of CSII (n = 105) and MII (n = 105) from 45 up to 65 years old and with a disease duration of> 5 years and above. In the present study, a clock drawing test (CDT) was used to identify dementia and cognitive impairment of the brain (executive works of the frontal lobe of the brain). The results of the comparative analysis showed that only in patients with type 2 diabetes from 45 to 50 years (n = 40) there were significant differences between the compared groups on the effectiveness of treatment (χ2 = 11.87, at a significance level of p <0.003) as compared with MII, which means among patients with type 2 diabetes with the method of treatment with CSII, there are less pronounced executive disorders of the frontal lobe of the brain and dementia, compared with patients with the method of treat-ment of MII. According to the results of the study, patients with type 2 diabetes of the first subgroup with the experience of the disease from 5 to 10 years (n = 114) had significant differences: the number of patients in whom dementia was not detected and cognitive impairments of the frontal lobe according to the PPII treatment were more , 1%), compared with the control group at MII (31.3%). Their difference was-24.8%. That is, manifestations of executive dysfunction of the frontal lobes of the brain and the presence of dementia were less susceptible to patients with the method of CSII. Conclusion: it is possible to consider CSII as one of the effective methods of preventing dementia and executive brain dysfunction among patients with type 2 diabetes from 45-50 years old, with an experience of the disease from 5 to 10 years. The remaining subgroups (by the duration of the disease from 11 years and above, as well as by age groups: from 51-55 years; 56-65 years) did not reveal the effect of CSII or MII. The earlier treatment is started with the CSII method, the less the manifestations of executive dysfunction in patients with type 2 diabetes and the develop-ment of dementia.

Item Type:	Article
Uncontrolled Keywords:	dementia, diabetes mellitus type 2, clock drawing test, cognitive function, continuous subcutaneous insulin infusion.
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Divisions:	Научно-практический журнал "Вестник КазНМУ" > Выпуск №4 2016 год
Depositing User:	Mr Askhat Zhakaev
Date Deposited:	02 Jul 2019 09:04
Last Modified:	02 Jul 2019 09:04
URI:	http://repository.kaznmu.kz/id/eprint/15557

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